Profile

Dr. Chueh received her Bachelor's and Master's degrees from the Department of Chemistry at National Chung Hsing University She was awarded a Ph.D. degree from Purdue University in 1997. After a few years of post-doctoral training, she began her academic career as an Assistant Professor in the Department of Life Sciences at Chung Shan Medical University in Taichung. In 2005, she transferred to the Institute of Biomedical Sciences at National Chung Hsing University in Taichung as an Assistant Professor. She was promoted to Associated Professor in 2009 and full Professor in 2013. Her research interest focus on the understanding biological function of a tumor-associated NADH oxidase (tNOX, ENOX2) that is universally expressed in many cancers. Given that tNOX is commonly expressed in cancer/transformed but not non-cancerous cells, its downregulation has become an important premise to explain the preferential cytotoxicity of capsaicin toward cancerous cells. Importantly, by utilizing cell lines from different tissues, we learned that several anticancer drugs can suppress tNOX activity/expression to reduce intracellular NAD+ concentration and an NAD+-dependent SIRT1 deacetylase activity, resulting in augmented p53 acetylation as well as apoptosis in cancer cells.

---

Research Area

Biochemistry、Cell Biology、Chemistry、Food Science and Biotechnology、Microbiology、Molecular Biology、Neuroscience、Pharmacology、Toxicology、Tumor biology